25 research outputs found

    A Novel Adaptive Proactive Secret Sharing without a Trusted Party

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    A (t+1,n)(t+1,n) proactive secret sharing is to protect a secret in long-lived system by distributing it to a group of nn participants and refreshing their shares periodically in this fixed group, while any t+1t+1 and more than t+1t+1 shares can reconstruct the secret. In some environment, it needs to change not only the number of participants nn but also the threshold value tt. An adaptive proactive secret sharing is to refresh the shares as tt and nn change. In this paper, we propose a novel adaptive proactive secret sharing scheme without a trusted party. Our proposed scheme is uniformly efficient and tolerates tt Byzantine faults in any single time interval, where the number of participants n≄3t+1n\geq 3t+1. The threshold value tt and the number of participants nn can be changed arbitrarily in two adjacent intervals. We also prove that our proposed scheme is secure under the discrete logarithm intractability assumption

    A Scalable Byzantine Fault Tolerant Service in Grid System

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    Abstract- This paper describes the design, implementation and usage of a secure scalable Byzantine fault tolerant MDS system in the Grid. The scalable Byzantine fault tolerant MDS system provides a hierarchy GIIS servers, a local GIIS domain can require the resource it needs from remote GIIS domain. By using the statemachine replication approach and quorum system technique, the scalable Byzantine fault tolerant MDS system can tolerate not only benign faults, but also arbitrary (Byzantine) ones. An optimizing key management and caching mechanism is also explored in this paper

    Online survey on healthcare skin reactions for wearing medical-grade protective equipment against COVID-19 in Hubei Province, China.

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    With the spread of Coronavirus Disease 2019 globally, more than 40,000 healthcare staff rushed to Wuhan, Hubei Province to fight against this threatening disease. All staff had to wear personal protective equipment (PPE) for several hours when caring for patients, which resulted in adverse skin reactions and injuries. In this study, we used an online questionnaire to collect the self-reported skin damages among the first-line medical staff in the epidemic. The questionnaire was designed by four front-line wound care nurses and then revised through Delphi consultants. Items mainly focused on the adverse skin reactions and preventive strategies. The survey was distributed through phone application from March 15th to March 20th and received 275 responses in total. The prevalence of skin reactions (212, 77.09%) was high in both head and hands. The common clinical symptoms of skin reactions were redness, device-like mark, and burning pain in face; and dryness, dermatitis, and itch/irritation in hands. Three risk factors included gender, level of protection, and daily wearing time of PPE were identified that caused skin reactions among medical staff. 150 of 275 (54.55%) participants took preventive strategies like prophylactic dressings, however, more than 75% users had little knowledge about dressings. We suggest the frontline staff strengthened the protection of skin integrity and reduced the prevalence of adverse skin reactions after professional education

    Biomass Production of Three Biofuel Energy Plants’ Use of a New Carbon Resource by Carbonic Anhydrase in Simulated Karst Soils: Mechanism and Capacity

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    To determine whether the bicarbonate in karst limestone soil could be used as a new carbon resource for biomass production by the catalysis of carbonic anhydrase (CA), a simulative karst drought stress experiment was designed and performed. Three plants used for biofuel energy, Orychophragmus violaceus L. (Ov), Brassica juncea L. (Bj), and Euphorbia lathyris L. (El), were grown under simulated karst drought stress. In response to drought stress, the photosynthesis of the three energy plants was inhibited, but their CA activity increased. The hypothesis was confirmed by plant physiological and stable isotope techniques. The obtained results showed that plant biomass was produced with atmospheric CO2 as well as bicarbonate under drought stress. Bicarbonate use was proportional to the CA activity of the plants. With high CA activity over a long period, El had the highest proportional bicarbonate use compared to Ov and Bj, reaching 26.95%. Additionally, a new method is proposed for the screening of plants grown for energy in karst habitats

    CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis

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    Abstract Snail is a denoted transcriptional repressor that plays key roles in epithelial-mesenchymal transition (EMT) and metastasis. Lately, a plethora of genes can be induced by stable expression of Snail in multiple cell lines. However, the biological roles of these upregulated genes are largely elusive. Here, we report identification of a gene encoding the key GlcNAc sulfation enzyme CHST2 is induced by Snail in multiple breast cancer cells. Biologically, CHST2 depletion results in inhibition of breast cancer cell migration and metastasis, while overexpression of CHST2 promotes cell migration and lung metastasis in nude mice. In addition, the expression level of MECA79 antigen is elevated and blocking the cell surface MECA79 antigen with specific antibodies can override cell migration mediated by CHST2 upregulation. Moreover, the sulfation inhibitor sodium chlorate effectively inhibits the cell migration induced by CHST2. Collectively, these data provide novel insights into the biology of Snail/CHST2/MECA79 axis in breast cancer progression and metastasis as well as potential therapeutic strategy for the diagnosis and treatment of breast cancer metastasis

    Sources and Dynamic Processes Controlling Background and Peak Concentrations of TGM in Nanjing, China

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    Total gaseous mercury (TGM) data from urban Nanjing, at the western edge of the Yangtze River Delta (YRD) region in China, over nine months, were analyzed for peak and background mercury concentrations. The background concentration of TGM was found to be 2.2 ng∙m−3. In examining episodic influences of free tropospheric air masses on the surface TGM concentrations in Nanjing, we hypothesize heterogeneity in the global distribution of TGM concentrations in the free troposphere. The nine-month averaged diurnal cycles of TGM indicate a strong co-emission with SO2 and an underestimation of greater than 80% TGM emissions in current inventories. Regular peak concentrations of mercury were investigated and the major causes were YRD emissions, transport from rural areas, and monsoonal transport. Transport of rural emissions is hypothesized to be from illegal artisanal small-scale gold mining that are currently missing in the emission inventories. Enhancement of TGM associated with summer monsoon contributed to a maximum TGM concentration in mid-May–early June, an inverse seasonality in comparison to most other observations in China, North America, and Europe
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